Hemostatic defects in liver and renal dysfunction

Hemostatic Dysfunction in Liver Diseases.

The liver plays a central role in hemostasis, as it is the site of synthesis of most procoagulant and anticoagulant factors. It also synthesizes many fibrinolytic proteins, and is an important source of thrombopoietin. Furthermore, it is involved in clearance of many hemostatic and fibrinolytic components. Consequently, patients with a decreased synthetic capacity of the liver acquire a complex...

Hemostatic defects in end stage liver disease.

End stage liver disease results in a complex and variably severe failure of hemostasis that predisposes to abnormal bleeding. The diverse spectrum of hemostatic defects includes impaired synthesis of clotting factors, excessive fibrinolysis, disseminated intravascular coagulation, thrombocytopenia, and platelet dysfunction. Hemostasis screening tests are used to assess disease severity and moni...

Hemostatic defects in dysproteinemias.

Bt1 HERBERT A. PE aNs, MALCOLM R. MACKENZIE AND H. HUGH FUDENBERG T HE ASSOCIATION OF HIGH CONCENTRATIONS of certain paraproteins and abnormal bleeding is well recognized, but the mechanism of defective hemostasis is uncertain. Numerous publications, generally restricted to single case reports or to small series of patients, describe a bewildering inconsistency of abnormal findings, some of whi...

Renal Dysfunction and Liver Transplantation

Liver transplantation, whether living donor (LDLT) or deceased donor (DDLT), is currently the treatment of choice for patients with advanced liver disease. While initially the focus was on acceptable short-term survival, currently the efforts are aimed at improving longterm prognosis. Thus, focus is now on the quality of life after liver transplantation, as well as prediction and management of ...

Renal dysfunction in chronic liver disease